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2019-10-17 14:26:23

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  “OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”

  Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”“OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.

  “OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.“OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”“OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.

  Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.

  AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”“OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.

  “OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.

  AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”“OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.

  AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.

  Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”

  AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.

  Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.“OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”

  Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”“OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”

  Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.“OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”

  Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  “OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”

  Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.“OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”“OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.

  Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.

  “OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.

  Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.

  Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”

  AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.

  Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.

  AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”“OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.

  “OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  “OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”

  “OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.Thereisnosecretformulaforasuccessfulcareerindrugdiscovery,butcreativityandthewillingnesstoadapttoarapidly-changingscientificlandscapeplaysabigrole.ForDr.DariaHazuda,VicePresidentofInfectiousDiseasesDiscovery,MSDResearchLaboratories,themostvaluabletraitistenacity,asmostresearchersareconsideredfortunateiftheycreatejustonenewmoleculethatmakesitthroughthecomplexprocessittakestobecomeaproduct.“WhenIjoinedMSDover20yearsago,itwasabigeye-openertoseethemagnitudeoftheeffortthatgoesintodrugdiscoveryanddevelopment,”shenotes.“Therearesomanydifferentdisciplinesrequiredtomovesomethingfromanideaindiscoveryintodevelopment,andthenthereissomucheffortrequiredalongthepathtoapproval.”Daria’sresearchininfectiousdiseasebiologyhasledtothediscoveryanddevelopmentofmultiplenovelmedicinestotreatHIVandHepatitisC.Butdon’tcallhersuccessinthisfieldlucky.“Luckmaybeafactor,sure,butmoreimportantly,youmustalsolearnfromthethingsthatdon’twork,”shesaysasshereflectsonherexperience.“Ifyouareworkingonaprogram,inevitablyalotofthethingsyoutrydon’tsucceed.Insteadofchalkingthoseuptofailure,usethoselessonsandapplythemtothenextiterationofwhatyouaretryingtodo.It’samissedopportunityifyoudon’tlearnfromwhatdoesn’twork.”Daria’sadvice:“Maintainfocusandhaveflexibilitytoadaptyourresearchasscienceanddataunfolds.”AdaptingMSD’sEarlyDiscoveryResearchWithDaria’sextensiveexperienceinthelabs(andmorethan180publicationsfocusedprimarilyonantiviralresearchinthefieldsofHIVandHepatitisC),DariawillnowapplyherexpertiseasChiefScientificOfficerofthenewMSDResearchLaboratoriesCambridgeexploratorysciencecenterinCambridge,Mass.Thecenterwillfocusontheearlieststagesofdiscoveryresearchtobetterunderstandtheunderlyingbiologyofhumandisease.“OurnewCambridgelabspresentauniqueopportunitytotapintothecutting-edgesciencecomingoutofthearea’srichbiomedicalresearch,”shesaysofthenewexploratorysciencecenter.Designedasanentrepreneurialandintimateenvironmentofroughly40scientists,thelabsdonotfocusontacklingasetrosterofdiseases.Here,theemphasiswillbeonexploringthemostpromisingareasofemergingdiseasebiology,includinghost-pathogenbiologyandtheroleofthemicrobiomeindisease,andgainingnewinsightstoinformMSD’songoingdrugdiscovery.”MSD’snewlabsarelocatedinCambridge’sKendallSquareneighborhood,hometooneofthelargestconcentrationsofbiotechandacademiaintheU.S.Inaddition,thespaceissharedwithMSD’sEastCoastBusinessDevelopmentteamtosupportthelab’sfocusonearlybiologyandtechnologycollaborationswithlocalacademicandbiotechgroups.ExploringemergingsciencetoinformdrugdiscoveryForDaria,expandingourearlyresearchcapabilitiesisanexcitingandnecessaryshiftforMSD,andademonstrationofourcommitmenttobeing“researchdriven.”Inalandscapewheremanylargebiopharmaceuticalcompaniesareexitingthediscoveryspace,sheseesthesenewcapabilitiesasanecessaryandvitaladditionforthecompany.“There’sareasonforthe‘and’inResearchandDevelopment,”Darianotes.“Youneedtohaveboth;youneedtohavepeopleexploringnewareasofbiologytouncovernewopportunitiestointerrogateadisease,aswellasthosewhorecognizewhatagoodmoleculelookslikeinordertomakeandsuccessfullydeliveramedicinetothemarket.”Lookingahead,sheadds,“What’smostexcitingtomeishavingtheflexibilitytoexplorecompletelynewareasofdiseasebiology,knowingthatwehaveMSD’sprovendiscoveryanddevelopmentcapabilitiesathandtodriveourdiscoveriesandinventionsforward.”“OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.

  “OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”“OnEarth,youcancontroleveryvariable–otherthangravity.”ThislittlenuggetofintergalacticwisdomaboutwhyconductingmedicalresearchaboardtheISSissoexcitingisfromTaraRuttley,anassociateprogramscientistfortheInternationalSpaceStation(ISS),duringarecenteventatMSD.Assheexplained,it’smainlybecausenoonereallyknowswhatwillhappeninzerogravity—ourusuallawsofphysicsjustdon’tapplyinouterspace.Zerogravityresearchallowsscientistsandresearcherstostudytheunderlyingdynamicsofwhythingsworkthewaytheydo.MSDscientistPaulReichertknowsthisfirsthand.He’sbeenworkingwithNASAandtheCenterfortheAdvancementofScienceinSpace(CASIS)toconducthisownsetofzerogravityexperimentsforMSDaboardtheISSsince1993.Paul,whohascarriedout13experiments,includingtwoonboardtheISS,hasonemainspecialty:growingcrystalsinspace.Improvingourdrugdiscovery,deliveryandmanufacturingprocessesAbouttenyearsago,Pauldiscoveredconditionsthatcrystallizeaproteincalled“alphainterferon.”We’lllethimexplain:“Proteinsgrowninspacebehavedifferentlybecausetheyarenotimpactedbytheforceofgravity,sotheytendtogrowbiggerandpurer,allowingustogainnewinsightsintotheir3-Dstructures,”henotes.“EachtimeI’vesentanexperimenttospace,I’velearnedhowtogrowcrystalsbetterhereonEarth.”PracticalapplicationsonEarthBymakingandstudyingthesecrystals,Paulandhisteamcanfigureoutwaystoimprovethestorageofotherwisestructurally-fragilemedicinesaswellashowtodevisebettermethodsofdrugdelivery.“Currently,alotofmedicinesaredeliveredviaanIVinahospitalsetting,usuallyoverseveralhours,”heexplains.WhatPaulandhisteamaretryingtofigureoutishowtotransformthesemedicinesintosomethingthatcanbegivenasasingle,quickinjectioninadoctor’soffice—somethingsomeonecanreceiveontheirlunchbreak,whereasbeforetheywouldhavetouseawholedayinordertogetthemedicinetheyneedtotake.“Akidinacandyshop”So,whatdoesthefutureholdforthisfrontier-bustingscientistHopefully,moreexperimentsandevenmorebreakthroughs.“MSDallowsme,everydayIcometowork,topushthefrontiersofscience,”henotes.“I’mlikeakidinacandyshophere.”Acandyshopthatjusthappenstosometimesbeinouterspace.

  AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”AsdirectorofAnalyticalMethodDevelopmentfortheBiologicsBioProcessDevelopmentgroup,DaisyRichardsonisthefirsttoadmitherroleisonethat’sabitmorebehind-the-scenes.“Myparents,neitherofwhomarescientists,askmeallthetimewhatIdo,”shesayswithalaugh.“Youneverreallythinkaboutdrugqualityandsafety.Peoplealwaysassumethereissomecontroloverit,buttheydon’trealizethecomplexitybehindit.Butthere’sthisincredibleintricacybehindthemoleculesinthevialorsyringeofmedicinetheyarereceiving.Itneedstobesafeandconsistent.”DaisyoverseesateamwhichcreatesteststomonitorthequalityofthemedicinesthatMSDmanufactures.“It’sabigresponsibility,”shenotes.“Sometimesthesetestsmighthavealifetimeof20or30years.SoyouneedtohaveavisiontomakesureMSDcontinuestomakeproductswhichremainsafeandconsistentduringthattimespan.”BecomingapositiverolemodelforothersDaisystrivestobearolemodelforotherwomeninherdepartment,aswellasforhertwoyoungdaughters.“It’swonderfulhowmanystrong,femaleleadersthereareinmydepartment.AndIthinkthatspeaksalottoMSDandtheirinvestmenttowomeninscience,”shenotes.HavingsomanyfemalecolleaguesisabitofanoveltyfortheMississippinative,whosaystherewereveryfewwomeninthesciencedisciplinesasshewasprogressingthroughschool.“Iwastheonlygirlinmyphysicsclassincollege,andonceIwastoldbymyprofessor,‘Youcantakethenotesbecauseyouarethewomanandyoucanbethesecretary.’Therejustweren’talotoffemalerolemodels.So,tome,beingarolemodelissomethingthatdrivesme.”WomencanbeleadersinscienceThatresponsibilitystartsathome.“Mytwogirlsaremybiggestsourcesofmotivationtocometoworkeveryday,”shesays.“It’sreallyimportantformetosetagoodexample,andtoshowmykidsthatwomencanbeinscience.Womencanbeleadersinscience,andtheycanbetechnicallystrong,andtheycansucceed.”Fornow,Daisy’soldestdaughterseemstobefollowinginhermom’sfootsteps.“Myoldestdaughter,whoisfour,isabletosignupfor‘elective’classesatherdaycare.Andshealwayssignsupforthescienceclass,”recallsDaisy.“Theotherdayshecamehome,ranuptomeandsaid,‘Mommy!Lookatme!I’mascientist!’Andshewassohappy.”Acommitmenttoinventingscientificsolutionstounmetmedicalchallenges…acommitmenttopatientsbeforeprofits…and,adeepsenseofcorporateobligationtothepublicgood.ThesearetheprinciplesGeorgeW.Merckestablishedforthecompanymanyyearsago,andtheycontinuetoguideourcompanyandleaderstoday.AMajorMilestoneCreatingMSD’sfirstcompleteresearchanddevelopmentlaboratory--onethatwassooutstandingthatitcould“talkonequaltermswiththeuniversitiesandresearchinstitutes”--wasamilestone…andnotjustforthecompanyandGeorgeMerck,whoinitiatedandledtheeffortasMSD’spresident.Itusheredinanewerainindustrialresearch--onethatfosteredcollaborationbetweenindustry,academiaandmedicalinstitutions.ItwasamilestoneforresearchersbothinsideandoutsideofMSD,and,mostimportantly,forthepatients.AnInterdisciplinaryResearchApproach–TheMSDCampusGeorgeMerckmadethedecisiontoinvestinthisworld-classR&Dfacilityin1929,inspiteofthefactthatthecountrywasenteringtheGreatDepression.Heenvisionedaplacewhere“sciencewillbeadvanced,knowledgeincreasedandhumanlifewillwinagreatfreedomfromsufferinganddisease.”Atthededicationceremonyin1933inRahway,N.J.,hefirstlaidoutthecompanymissiontodevelopscientificbreakthroughstobenefithumanity,andthencarefullybuilttheteamofscientistsandstrategyofscientificinnovationthatdefinesthecompany.Knownas“TheMSDCampus”becauseofitsacademicatmosphereandappearance,thenewR&Dfacilityofferedscientists“thegreatestpossiblelatitudeandscopeinpursuingtheirinvestigations,theutmostfreedomtofollowpromisingscientificresultsnomatterhowunrelatedtowhatonewouldcallpracticalterms”andthefreedomtopublish.And,itreflectedasignificantshiftintherelationshipbetweenbusinessanduniversitiesthathadbeenunwillingtoendangertheirautonomybyworkingwithindustry.AccordingtoGeorgeMerck,“thenewlaboratoriessignifiedourtransitionfromthemoreorlessindividual,isolatedscientificefforttomodernteamwork.MSD’scollaborationwithacademicandmedicalinstitutionsflourishedandyieldedimportantpioneeringdiscoveriesatthattime,amongthem:vitamins,antibioticsandhormones.ShiftfromchemicalmanufacturertopharmaceuticalcompanyGeorgeMerckguidedthecompanythroughtwodecisivemergers.Thefirst,in1927,wasthemergerofPowers-Weightman-Rosengartenthatmorethandoubledthecompany’ssales.Thesecond,the1953mergerwithSharp&Dohme,resultedinafullyintegrated,multi-nationalproduceranddistributorofpharmaceuticalsaswellasspecialtychemicals.AfocusonpatientsandcorporateresponsibilityGeorgeMerckindoctrinatedthecompany–andthroughit,eventually,theindustry–withtheconceptthatthepublicgoodmustbetakenintoaccountasafactorinitspoliciesandprojects.Hesaid:Itisuptousinresearchwork,inindustries,andincollegesandotherinstitutions,tohelpkeeptheprobleminthisfocus.Wecannotstepasideandsaythatwehaveachievedourgoalbyinventinganewdrugoranewwaybywhichtotreatpresentlyincurablediseases,anewwaytohelpthosewhosufferfrommalnutrition,orthecreationofidealbalanceddietsonaworldwidescale.Wecannotresttillthewayhasbeenfound,withourhelp,tobringourfinestachievementtoeveryone.ThisresponsibilitywasevidentwhenGeorgeMerckturnedoverMSDspatentrightstothebreakthroughantibioticfortuberculosisdiscoveredbyDr.SelmanWaksmanatRutgersUniversitywithsupportfromMSD,sothatthispublic-healthprocesscouldbelicensedtomultiplemanufacturersforthebenefitofthemanypeoplesufferinganddyingfromthisdisease.GuidingourfutureEncouragedbyhisfathertojointheshopin1915,GeorgeMerckrevolutionizedpharmaceuticalresearchandlaunchedsomeofthemostexcitinginnovationsinMSDshistory.Hewasavisionarywhosevaluesandprinciplesstillguidethiscompanymorethan90yearslater.KenFrazier,MSDchairmanandCEO,recentlynoted,OurcompanysenduringpurposewascapturedbyGeorgeW.Merck,whosaidmedicineisforthepeople,notfortheprofits.It'simportantforusnotonlytodiscoveranddevelopinnovativemedicines,butalsotomakesurethatpeoplehaveaccesstothosemedicines.Onaquesttocure,wecontinuetoholdGeorgeW.Mercksvaluestothehigheststandard.Valuesofthepastguideourvisionforahealthierandmorehopefulfuture.

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